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    Immune function in hypopituitarism; time to reconsider?

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    Authors
    Mukherjee, Annice
    Helbert, M
    Davis, J R E
    Shalet, Stephen M
    Affiliation
    Dept of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    2009-12-18
    
    Metadata
    Show full item record
    Abstract
    Abstract Hypopituitarism is not currently considered as a potential cause of immune disruption in humans. Accumulating data from in-vitro and animal models support a role for the pituitary gland in immune regulation. Furthermore the increased mortality risk noted in patients with adult hypopituitarism remains poorly explained and immune dysfunction could conceivably contribute to this observation. In a recent issue of Clinical & Experimental Immunology we presented new data relating to immune status in adults with treated, severe hypopituitarism. We observed humoral immune deficiency in a significant proportion, despite stable pituitary replacement, including growth hormone (GH). This was especially evident in those with low pre-treatment IGF-I levels and appeared independent of anticonvulsant use or corticosteroid replacement. These observations require substantiation with future studies. In this short review we summarise existing data relating to the effects of pituitary hormones on immune function, and discuss potential clinical implications surrounding the hypothesis of immune dysregulation in severe hypopituitarism.
    Citation
    Immune function in hypopituitarism; time to reconsider? 2009: Clin Endocrinol
    Journal
    Clinical Endocrinology
    URI
    http://hdl.handle.net/10541/115787
    DOI
    10.1111/j.1365-2265.2009.03751.x
    PubMed ID
    20039902
    Type
    Article
    Language
    en
    ISSN
    1365-2265
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2265.2009.03751.x
    Scopus Count
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    All Christie Publications
    Endocrinology

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