Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.
dc.contributor.author | Khan, A R | |
dc.contributor.author | Dovedi, Simon J | |
dc.contributor.author | Wilkinson, R W | |
dc.contributor.author | Pritchard, D I | |
dc.date.accessioned | 2010-11-17T15:26:36Z | |
dc.date.available | 2010-11-17T15:26:36Z | |
dc.date.issued | 2010-10 | |
dc.identifier.citation | Tumor infiltrating regulatory T cells: tractable targets for immunotherapy. 2010, 29 (5):461-84 Int Rev Immunol | en |
dc.identifier.issn | 1563-5244 | |
dc.identifier.pmid | 20839911 | |
dc.identifier.doi | 10.3109/08830185.2010.508854 | |
dc.identifier.uri | http://hdl.handle.net/10541/115717 | |
dc.description.abstract | Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention. | |
dc.language.iso | en | en |
dc.subject | Regulatory Tumour Cells | en |
dc.subject | Tumour | en |
dc.subject | CTLA-4 | en |
dc.subject | GITR | en |
dc.title | Tumor infiltrating regulatory T cells: tractable targets for immunotherapy. | en |
dc.type | Article | en |
dc.contributor.department | Doctoral Training Centre for Targeted Therapeutics, School of Pharmacy, University of Nottingham, Nottingham, UK. | en |
dc.identifier.journal | International Reviews of Immunology | en |
html.description.abstract | Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention. |