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dc.contributor.authorKhan, A R
dc.contributor.authorDovedi, Simon J
dc.contributor.authorWilkinson, R W
dc.contributor.authorPritchard, D I
dc.date.accessioned2010-11-17T15:26:36Z
dc.date.available2010-11-17T15:26:36Z
dc.date.issued2010-10
dc.identifier.citationTumor infiltrating regulatory T cells: tractable targets for immunotherapy. 2010, 29 (5):461-84 Int Rev Immunolen
dc.identifier.issn1563-5244
dc.identifier.pmid20839911
dc.identifier.doi10.3109/08830185.2010.508854
dc.identifier.urihttp://hdl.handle.net/10541/115717
dc.description.abstractSeveral studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.
dc.language.isoenen
dc.subjectRegulatory Tumour Cellsen
dc.subjectTumouren
dc.subjectCTLA-4en
dc.subjectGITRen
dc.titleTumor infiltrating regulatory T cells: tractable targets for immunotherapy.en
dc.typeArticleen
dc.contributor.departmentDoctoral Training Centre for Targeted Therapeutics, School of Pharmacy, University of Nottingham, Nottingham, UK.en
dc.identifier.journalInternational Reviews of Immunologyen
html.description.abstractSeveral studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.


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