Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.
Affiliation
Doctoral Training Centre for Targeted Therapeutics, School of Pharmacy, University of Nottingham, Nottingham, UK.Issue Date
2010-10
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Show full item recordAbstract
Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.Citation
Tumor infiltrating regulatory T cells: tractable targets for immunotherapy. 2010, 29 (5):461-84 Int Rev ImmunolJournal
International Reviews of ImmunologyDOI
10.3109/08830185.2010.508854PubMed ID
20839911Type
ArticleLanguage
enISSN
1563-5244ae974a485f413a2113503eed53cd6c53
10.3109/08830185.2010.508854
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