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    Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.

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    Authors
    Khan, A R
    Dovedi, Simon J
    Wilkinson, R W
    Pritchard, D I
    Affiliation
    Doctoral Training Centre for Targeted Therapeutics, School of Pharmacy, University of Nottingham, Nottingham, UK.
    Issue Date
    2010-10
    
    Metadata
    Show full item record
    Abstract
    Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.
    Citation
    Tumor infiltrating regulatory T cells: tractable targets for immunotherapy. 2010, 29 (5):461-84 Int Rev Immunol
    Journal
    International Reviews of Immunology
    URI
    http://hdl.handle.net/10541/115717
    DOI
    10.3109/08830185.2010.508854
    PubMed ID
    20839911
    Type
    Article
    Language
    en
    ISSN
    1563-5244
    ae974a485f413a2113503eed53cd6c53
    10.3109/08830185.2010.508854
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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