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    Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

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    Authors
    Barnwell, E M
    Van Deursen, Frederick
    Jeacock, L
    Smith, K A
    Maizels, R M
    Acosta-Serrano, A
    Matthews, K
    Affiliation
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, Kings' Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.
    Issue Date
    2010-10-01
    
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    Abstract
    Trypanosomes evade host immunity by exchanging variant surface glycoprotein (VSG) coats. VSG genes are transcribed from telomeric expression sites, which contain a diverse family of expression-site-associated genes (ESAGs). We have discovered that the mRNAs for one ESAG family, ESAG9, are strongly developmentally regulated, being enriched in stumpy forms, a life-cycle stage in the mammalian bloodstream that is important for the maintenance of chronic parasite infections and for tsetse transmission. ESAG9 gene sequences are highly diverse in the genome and encode proteins with weak similarity to the massively diverse MASP proteins in Trypanosoma cruzi. We demonstrate that ESAG9 proteins are modified by N-glycosylation and can be shed to the external milieu, this being dependent upon coexpression with at least one other family member. The expression profile and extracellular release of ESAG9 proteins represents a novel and unexpected aspect of the transmission biology of trypanosomes in their mammalian host. We suggest that these molecules might interact with the external environment, with possible implications for infection chronicity or parasite transmission.
    Citation
    Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms. 2010, 123 (Pt 19):3401-11 J Cell Sci
    Journal
    Journal of Cell Science
    URI
    http://hdl.handle.net/10541/115716
    DOI
    10.1242/jcs.068684
    PubMed ID
    20826456
    Type
    Article
    Language
    en
    ISSN
    1477-9137
    ae974a485f413a2113503eed53cd6c53
    10.1242/jcs.068684
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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