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dc.contributor.authorChen, Fu-Du
dc.contributor.authorHendry, Jolyon H
dc.date.accessioned2010-11-11T16:17:43Z
dc.date.available2010-11-11T16:17:43Z
dc.date.issued1988-02
dc.identifier.citationRe-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints. 1988, 11 (2):153-9 Radiother Oncolen
dc.identifier.issn0167-8140
dc.identifier.pmid3353519
dc.identifier.doi10.1016/0167-8140(88)90251-4
dc.identifier.urihttp://hdl.handle.net/10541/115441
dc.description.abstractThe amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFemale
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshNecrosis
dc.subject.meshSkin
dc.subject.meshStem Cells
dc.subject.meshWound Healing
dc.titleRe-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractThe amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.


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