Re-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints.
AffiliationDepartment of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
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AbstractThe amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.
CitationRe-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints. 1988, 11 (2):153-9 Radiother Oncol
JournalRadiotherapy and Oncology