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dc.contributor.authorZaloudik, J
dc.contributor.authorMoore, Michael
dc.contributor.authorHasleton, Philip S
dc.date.accessioned2010-11-10T17:13:23Z
dc.date.available2010-11-10T17:13:23Z
dc.date.issued1988
dc.identifier.citationThe DNA content of colorectal carcinomas: an analysis of the heterogeneity of aneuploidy and correlation with immunopathological parameters. 1988, 35 (4):389-401 Neoplasmaen
dc.identifier.issn0028-2685
dc.identifier.pmid3054589
dc.identifier.urihttp://hdl.handle.net/10541/115332
dc.descriptionColorectal Neoplasms DNA, Neoplasmen
dc.description.abstractDNA ploidy patterns of 107 colorectal adenocarcinomas were retrospectively analyzed by flow cytometry (FCM) and correlated with clinicopathological and immunohistological parameters as grade, vascular and serosal invasion, carcinoembryonic antigen, secretory component (SC) and expression of HLA-DR antigens. Using the classical division into DNA diploid and DNA aneuploid tumors, a correlation with SC expression was observed. Subdivision of aneuploid tumors according to the discussed hypothetical functional criteria into hyperdiploid, hypotetraploid, tetraploid and hypertetraploid groups led to statistically significant correlation with serosal invasion. Among the immunohistological parameters the interdependence of SC and HLA-DR expression may be also of interest. The need for subdivision of DNA aneuploidy is broadly discussed so as to permit the analysis of different properties, cellular origins and kinetic parameters. Ultimately this may lead to more clinically meaningful interpretation of DNA histograms.
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectCancer DNAen
dc.subject.meshAdenocarcinoma
dc.subject.meshAneuploidy
dc.subject.meshCarcinoembryonic Antigen
dc.subject.meshColon
dc.subject.meshColorectal Neoplasms
dc.subject.meshDNA, Neoplasm
dc.subject.meshFlow Cytometry
dc.subject.meshHLA-DR Antigens
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshMitotic Index
dc.subject.meshPloidies
dc.subject.meshSecretory Component
dc.titleThe DNA content of colorectal carcinomas: an analysis of the heterogeneity of aneuploidy and correlation with immunopathological parameters.en
dc.typeArticleen
dc.contributor.departmentResearch Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.en
dc.identifier.journalNeoplasmaen
html.description.abstractDNA ploidy patterns of 107 colorectal adenocarcinomas were retrospectively analyzed by flow cytometry (FCM) and correlated with clinicopathological and immunohistological parameters as grade, vascular and serosal invasion, carcinoembryonic antigen, secretory component (SC) and expression of HLA-DR antigens. Using the classical division into DNA diploid and DNA aneuploid tumors, a correlation with SC expression was observed. Subdivision of aneuploid tumors according to the discussed hypothetical functional criteria into hyperdiploid, hypotetraploid, tetraploid and hypertetraploid groups led to statistically significant correlation with serosal invasion. Among the immunohistological parameters the interdependence of SC and HLA-DR expression may be also of interest. The need for subdivision of DNA aneuploidy is broadly discussed so as to permit the analysis of different properties, cellular origins and kinetic parameters. Ultimately this may lead to more clinically meaningful interpretation of DNA histograms.


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