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    The DNA content of colorectal carcinomas: an analysis of the heterogeneity of aneuploidy and correlation with immunopathological parameters.

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    Authors
    Zaloudik, J
    Moore, Michael
    Hasleton, Philip S
    Affiliation
    Research Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.
    Issue Date
    1988
    
    Metadata
    Show full item record
    Abstract
    DNA ploidy patterns of 107 colorectal adenocarcinomas were retrospectively analyzed by flow cytometry (FCM) and correlated with clinicopathological and immunohistological parameters as grade, vascular and serosal invasion, carcinoembryonic antigen, secretory component (SC) and expression of HLA-DR antigens. Using the classical division into DNA diploid and DNA aneuploid tumors, a correlation with SC expression was observed. Subdivision of aneuploid tumors according to the discussed hypothetical functional criteria into hyperdiploid, hypotetraploid, tetraploid and hypertetraploid groups led to statistically significant correlation with serosal invasion. Among the immunohistological parameters the interdependence of SC and HLA-DR expression may be also of interest. The need for subdivision of DNA aneuploidy is broadly discussed so as to permit the analysis of different properties, cellular origins and kinetic parameters. Ultimately this may lead to more clinically meaningful interpretation of DNA histograms.
    Citation
    The DNA content of colorectal carcinomas: an analysis of the heterogeneity of aneuploidy and correlation with immunopathological parameters. 1988, 35 (4):389-401 Neoplasma
    Journal
    Neoplasma
    URI
    http://hdl.handle.net/10541/115332
    PubMed ID
    3054589
    Type
    Article
    Language
    en
    Description
    Colorectal Neoplasms DNA, Neoplasm
    ISSN
    0028-2685
    Collections
    All Paterson Institute for Cancer Research

    entitlement

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