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    Inhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin.

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    Authors
    Young, A R
    Potten, Christopher S
    Chadwick, Caroline A
    Murphy, G M
    Cohen, A J
    Affiliation
    Photobiology Unit, Institute of Dermatology, St. Thomas's Hospital, London, UK.
    Issue Date
    1988
    
    Metadata
    Show full item record
    Abstract
    Previously untanned buttock skin of 4 volunteers (skin type II; tan with difficulty as they sunburn easily) was treated with various sunscreen preparations and solar--simulated radiation (SSR) or SSR alone for 2 weeks. One week later, the treatment sites were challenged with a DNA-damaging dose of SSR--twice the minimal erythema dose (2 MED). Skin biopsy samples were assayed for the levels of unscheduled DNA synthesis (a measure of DNA damage), melanin distribution, and skin thickening. 5-Methoxypsoralen-containing sunscreen preparations plus SSR or SSR alone induced melanogenesis and increased the stratum corneum thickness, but only the former regimen afforded a high degree of protection against subsequent SSR-induced DNA damage. 5-Methoxypsoralen-free sunscreen preparations plus SSR induced negligible tanning, skin thickening, and photoprotection. These findings are relevant to the risk-benefit analysis of sunscreen preparations, especially in skin type II, as they provide evidence that a 5-methoxypsoralen-induced tan is protective against the DNA-damaging effects of solar UV radiation, and thus has the potential to reduce the carcinogenic risk of exposure to such radiation.
    Citation
    Inhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin. 1988, 1 (5):350-4 Pigment Cell Res
    Journal
    Pigment Cell Research
    URI
    http://hdl.handle.net/10541/115330
    PubMed ID
    3237602
    Type
    Article
    Language
    en
    ISSN
    0893-5785
    Collections
    All Paterson Institute for Cancer Research

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