Inhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin.
Affiliation
Photobiology Unit, Institute of Dermatology, St. Thomas's Hospital, London, UK.Issue Date
1988
Metadata
Show full item recordAbstract
Previously untanned buttock skin of 4 volunteers (skin type II; tan with difficulty as they sunburn easily) was treated with various sunscreen preparations and solar--simulated radiation (SSR) or SSR alone for 2 weeks. One week later, the treatment sites were challenged with a DNA-damaging dose of SSR--twice the minimal erythema dose (2 MED). Skin biopsy samples were assayed for the levels of unscheduled DNA synthesis (a measure of DNA damage), melanin distribution, and skin thickening. 5-Methoxypsoralen-containing sunscreen preparations plus SSR or SSR alone induced melanogenesis and increased the stratum corneum thickness, but only the former regimen afforded a high degree of protection against subsequent SSR-induced DNA damage. 5-Methoxypsoralen-free sunscreen preparations plus SSR induced negligible tanning, skin thickening, and photoprotection. These findings are relevant to the risk-benefit analysis of sunscreen preparations, especially in skin type II, as they provide evidence that a 5-methoxypsoralen-induced tan is protective against the DNA-damaging effects of solar UV radiation, and thus has the potential to reduce the carcinogenic risk of exposure to such radiation.Citation
Inhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin. 1988, 1 (5):350-4 Pigment Cell ResJournal
Pigment Cell ResearchPubMed ID
3237602Type
ArticleLanguage
enISSN
0893-5785Collections
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