Inhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin.
AffiliationPhotobiology Unit, Institute of Dermatology, St. Thomas's Hospital, London, UK.
MetadataShow full item record
AbstractPreviously untanned buttock skin of 4 volunteers (skin type II; tan with difficulty as they sunburn easily) was treated with various sunscreen preparations and solar--simulated radiation (SSR) or SSR alone for 2 weeks. One week later, the treatment sites were challenged with a DNA-damaging dose of SSR--twice the minimal erythema dose (2 MED). Skin biopsy samples were assayed for the levels of unscheduled DNA synthesis (a measure of DNA damage), melanin distribution, and skin thickening. 5-Methoxypsoralen-containing sunscreen preparations plus SSR or SSR alone induced melanogenesis and increased the stratum corneum thickness, but only the former regimen afforded a high degree of protection against subsequent SSR-induced DNA damage. 5-Methoxypsoralen-free sunscreen preparations plus SSR induced negligible tanning, skin thickening, and photoprotection. These findings are relevant to the risk-benefit analysis of sunscreen preparations, especially in skin type II, as they provide evidence that a 5-methoxypsoralen-induced tan is protective against the DNA-damaging effects of solar UV radiation, and thus has the potential to reduce the carcinogenic risk of exposure to such radiation.
CitationInhibition of UV radiation-induced DNA damage by a 5-methoxypsoralen tan in human skin. 1988, 1 (5):350-4 Pigment Cell Res
JournalPigment Cell Research
- The time of onset and duration of 5-methoxypsoralen photochemoprotection from UVR-induced DNA damage in human skin.
- Authors: Chadwick CA, Potten CS, Cohen AJ, Young AR
- Issue date: 1994 Oct
- Photoprotection and 5-MOP photochemoprotection from UVR-induced DNA damage in humans: the role of skin type.
- Authors: Young AR, Potten CS, Chadwick CA, Murphy GM, Hawk JL, Cohen AJ
- Issue date: 1991 Nov
- DNA damage in UV-irradiated human skin in vivo: automated direct measurement by image analysis (thymine dimers) compared with indirect measurement (unscheduled DNA synthesis) and protection by 5-methoxypsoralen.
- Authors: Potten CS, Chadwick CA, Cohen AJ, Nikaido O, Matsunaga T, Schipper NW, Young AR
- Issue date: 1993 Mar
- Tanning in human skin types II and III offers modest photoprotection against erythema.
- Authors: Sheehan JM, Potten CS, Young AR
- Issue date: 1998 Oct
- 5-MOP induced protection against epidermal DNA damage by ultraviolet radiation in human skin.
- Authors: Young AR, Potten CS, Chadwick CA, Murphy GM, Cohen AJ
- Issue date: 1990