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    Assignment of ecto-5'-nucleotidase to human chromosome 6.

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    Authors
    Boyle, John M
    Hey, Yvonne
    Guerts van Kessel, A
    Fox, M
    Affiliation
    Department of Biochemical Genetics, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
    Issue Date
    1988-12
    
    Metadata
    Show full item record
    Abstract
    Ecto-5'-nucleotidase activity (5NT) was measured on whole cells of 26 human x Chinese hamster hybrids. Concordance analysis showed 100% correlation between enzyme activity and inheritance of human chromosome 6. This observation was confirmed by a segregation analysis in which cells of a hybrid containing chromosome 6 were stained by indirect immunofluorescence for HLA Class 1 antigen and sorted by a fluorescence-activated cell sorter (FACS). Cells in the HLA- compartment were cloned and expression of HLA and 5NT was determined. Of nine clones, three were HLA-, 5NT- and six were HLA+, 5NT+, supporting the linkage of 5NT to chromosome 6.
    Citation
    Assignment of ecto-5'-nucleotidase to human chromosome 6. 1988, 81 (1):88-92 Hum. Genet.
    Journal
    Human Genetics
    URI
    http://hdl.handle.net/10541/115258
    DOI
    10.1007/BF00283737
    PubMed ID
    2848759
    Type
    Article
    Language
    en
    ISSN
    0340-6717
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00283737
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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