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DNA ploidy in bronchopulmonary carcinoid tumours.

dc.contributor.authorJones, D J
dc.contributor.authorHasleton, Philip S
dc.contributor.authorMoore, Michael
dc.date.accessioned2010-11-10T11:19:13Z
dc.date.available2010-11-10T11:19:13Z
dc.date.issued1988-03
dc.identifier.citationDNA ploidy in bronchopulmonary carcinoid tumours. 1988, 43 (3):195-9 Thoraxen
dc.identifier.issn0040-6376
dc.identifier.pmid3406904
dc.identifier.doi10.1136/thx.43.3.195
dc.identifier.urihttp://hdl.handle.net/10541/115238
dc.description.abstractFifty three bronchopulmonary carcinoid tumours were studied to assess the significance of DNA ploidy, determined by flow cytometry of paraffin embedded tissue. Twenty eight were typical carcinoid tumours and 25 well differentiated neuroendocrine carcinomas. Twenty seven were DNA diploid and 26 DNA aneuploid. DNA aneuploidy was significantly associated with histological features of increased malignant potential. Survival data were available for 43 patients. Of the 19 with DNA diploid tumours, 16 survived five years, compared with 14 of 24 with DNA aneuploid tumours--the difference being at the borderline of statistical significance. In a Cox multivariate regression analysis with other histological variables, DNA ploidy did not confer independent prognostic information. It is concluded that, although DNA aneuploidy as determined by flow cytometry is an indicator of increased malignant potential in bronchopulmonary carcinoid tumours, it does not provide clinically useful information additional to the results of routine histological examination.
dc.language.isoenen
dc.subjectCarcinoid Tumouren
dc.subjectLung Canceren
dc.subject.meshCarcinoid Tumor
dc.subject.meshDNA
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshPloidies
dc.subject.meshPrognosis
dc.titleDNA ploidy in bronchopulmonary carcinoid tumours.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester.en
dc.identifier.journalThoraxen
html.description.abstractFifty three bronchopulmonary carcinoid tumours were studied to assess the significance of DNA ploidy, determined by flow cytometry of paraffin embedded tissue. Twenty eight were typical carcinoid tumours and 25 well differentiated neuroendocrine carcinomas. Twenty seven were DNA diploid and 26 DNA aneuploid. DNA aneuploidy was significantly associated with histological features of increased malignant potential. Survival data were available for 43 patients. Of the 19 with DNA diploid tumours, 16 survived five years, compared with 14 of 24 with DNA aneuploid tumours--the difference being at the borderline of statistical significance. In a Cox multivariate regression analysis with other histological variables, DNA ploidy did not confer independent prognostic information. It is concluded that, although DNA aneuploidy as determined by flow cytometry is an indicator of increased malignant potential in bronchopulmonary carcinoid tumours, it does not provide clinically useful information additional to the results of routine histological examination.


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