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    Reaction between ortho-semiquinones and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies.

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    Authors
    Kalyanaraman, B
    Korytowski, W
    Pilas, B
    Sarna, T
    Land, Edward J
    Truscott, T G
    Affiliation
    Department of Radiology, Medical College of Wisconsin, Milwaukee 53226.
    Issue Date
    1988-10
    
    Metadata
    Show full item record
    Abstract
    The cytotoxicity to tumor cells or cardiotoxic side effects of certain para-quinone antitumor drugs have been attributed to the corresponding semiquinones and derived superoxide and hydroxyl radicals. It has also been suggested that ortho-semiquinones, including those that arise during melanogenesis, produced via either the one-electron oxidation of catechol(amine)s or the one-electron reduction of the corresponding quinones, react with molecular oxygen to give superoxide and hydrogen peroxide. Furthermore it has been shown that catechol(amine)s which form noncyclizable quinones are more cytotoxic toward melanogenic cells than those forming cyclizable quinones. In order to provide further kinetic information on the interaction of oxygen with ortho-semiquinones, using pulse radiolysis we directly measured the rates of reaction of various ortho-semiquinones with molecular oxygen. The semiquinones of the corresponding catechol(amine)s were also produced by the horseradish peroxidase/hydrogen peroxide system, and detected by electron spin resonance spectroscopy using the spin stabilization method. Oxygen consumption was monitored using a standard Clark oxygen electrode. Our data indicate that while ortho-semiquinones from catechol(amine)s and catechol estrogens do not react with molecular oxygen at a rate equal to or greater than k less than or equal to 10(5) M-1 s-1, semiquinones from hydroxy-substituted catechol(amine)s react with dioxygen with rates in the range k = 10(6)-10(7) M-1 s-1.
    Citation
    Reaction between ortho-semiquinones and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies. 1988, 266 (1):277-84 Arch Biochem Biophys
    Journal
    Archives of Biochemistry and Biophysics
    URI
    http://hdl.handle.net/10541/115237
    PubMed ID
    2845864
    PubMed Central ID
    10.1016/0003-9861(88)90259-7
    Type
    Article
    Language
    en
    ISSN
    0003-9861
    Collections
    All Paterson Institute for Cancer Research

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