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dc.contributor.authorLaskay, Gabor
dc.contributor.authorDale, Robert E
dc.contributor.authorJelínek, Jaroslav
dc.contributor.authorSpooncer, Elaine
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-11-10T10:58:26Z
dc.date.available2010-11-10T10:58:26Z
dc.date.issued1988
dc.identifier.citationInterleukin-3-specific modification of cell membrane "fluidity" of haemopoietic cells. 1988, 1 (1):67-73 Growth Factorsen
dc.identifier.issn0897-7194
dc.identifier.pmid3272800
dc.identifier.doi10.3109/08977198809000248
dc.identifier.urihttp://hdl.handle.net/10541/115236
dc.description.abstractThe work reported here clearly demonstrates that a specific growth factor, interleukin-3 (IL-3), which acts on multipotent haemopoietic stem cells as well as on committed myeloid progenitor cells of different lineages (Schrader, 1988; Whetton and Dexter, 1986), specifically induces a modification of the physical state ("fluidity") of the cell membranes of two IL-3-responsive and apparently normal haemopoietic cell lines. Furthermore, in a derived IL-3 independent myeloid leukaemic cell line, no such physical response to IL-3 binding was observed. The rapidity of the "normal" response suggests further that it may be associated with, or even constitute per se a critical early effect elicited by IL-3 in sensitive cells, the necessity for which is abrogated in the malignant derivative.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals
dc.subject.meshCell Line
dc.subject.meshCell Membrane
dc.subject.meshDiphenylhexatriene
dc.subject.meshFluorescence Polarization
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshInterleukin-3
dc.subject.meshKinetics
dc.subject.meshMembrane Fluidity
dc.subject.meshMice
dc.titleInterleukin-3-specific modification of cell membrane "fluidity" of haemopoietic cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biophysics, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.en
dc.identifier.journalGrowth Factorsen
html.description.abstractThe work reported here clearly demonstrates that a specific growth factor, interleukin-3 (IL-3), which acts on multipotent haemopoietic stem cells as well as on committed myeloid progenitor cells of different lineages (Schrader, 1988; Whetton and Dexter, 1986), specifically induces a modification of the physical state ("fluidity") of the cell membranes of two IL-3-responsive and apparently normal haemopoietic cell lines. Furthermore, in a derived IL-3 independent myeloid leukaemic cell line, no such physical response to IL-3 binding was observed. The rapidity of the "normal" response suggests further that it may be associated with, or even constitute per se a critical early effect elicited by IL-3 in sensitive cells, the necessity for which is abrogated in the malignant derivative.


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