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    Interleukin-3-specific modification of cell membrane "fluidity" of haemopoietic cells.

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    Authors
    Laskay, Gabor
    Dale, Robert E
    Jelínek, Jaroslav
    Spooncer, Elaine
    Dexter, T Michael
    Affiliation
    Department of Biophysics, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, United Kingdom.
    Issue Date
    1988
    
    Metadata
    Show full item record
    Abstract
    The work reported here clearly demonstrates that a specific growth factor, interleukin-3 (IL-3), which acts on multipotent haemopoietic stem cells as well as on committed myeloid progenitor cells of different lineages (Schrader, 1988; Whetton and Dexter, 1986), specifically induces a modification of the physical state ("fluidity") of the cell membranes of two IL-3-responsive and apparently normal haemopoietic cell lines. Furthermore, in a derived IL-3 independent myeloid leukaemic cell line, no such physical response to IL-3 binding was observed. The rapidity of the "normal" response suggests further that it may be associated with, or even constitute per se a critical early effect elicited by IL-3 in sensitive cells, the necessity for which is abrogated in the malignant derivative.
    Citation
    Interleukin-3-specific modification of cell membrane "fluidity" of haemopoietic cells. 1988, 1 (1):67-73 Growth Factors
    Journal
    Growth Factors
    URI
    http://hdl.handle.net/10541/115236
    DOI
    10.3109/08977198809000248
    PubMed ID
    3272800
    Type
    Article
    Language
    en
    ISSN
    0897-7194
    ae974a485f413a2113503eed53cd6c53
    10.3109/08977198809000248
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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