Show simple item record

dc.contributor.authorEwen, C
dc.contributor.authorPerera, A
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorMcAuliffe, C A
dc.contributor.authorSharma, H
dc.contributor.authorFox, Brian W
dc.date.accessioned2010-11-10T10:39:43Z
dc.date.available2010-11-10T10:39:43Z
dc.date.issued1988
dc.identifier.citationAn autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin. 1988, 22 (3):241-5 Cancer Chemother. Pharmacol.en
dc.identifier.issn0344-5704
dc.identifier.pmid3044632
dc.identifier.doi10.1007/BF00273418
dc.identifier.urihttp://hdl.handle.net/10541/115231
dc.description.abstractThe intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.
dc.language.isoenen
dc.subjectAnticancerous Agentsen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshAutoradiography
dc.subject.meshCarboplatin
dc.subject.meshCisplatin
dc.subject.meshIsotope Labeling
dc.subject.meshKidney
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshOrganoplatinum Compounds
dc.subject.meshPlatinum
dc.subject.meshQuality Control
dc.subject.meshRadioisotopes
dc.titleAn autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractThe intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.


This item appears in the following Collection(s)

Show simple item record