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    An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin.

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    Authors
    Ewen, C
    Perera, A
    Hendry, Jolyon H
    McAuliffe, C A
    Sharma, H
    Fox, Brian W
    Affiliation
    Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
    Issue Date
    1988
    
    Metadata
    Show full item record
    Abstract
    The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.
    Citation
    An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin. 1988, 22 (3):241-5 Cancer Chemother. Pharmacol.
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/115231
    DOI
    10.1007/BF00273418
    PubMed ID
    3044632
    Type
    Article
    Language
    en
    ISSN
    0344-5704
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00273418
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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