• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The light and electron microscopic features of early and late phase radiation-induced proctitis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Haboubi, N Y
    Schofield, Philip F
    Rowland, P L
    Affiliation
    Department of Surgery, University Hospital of South Manchester, England.
    Issue Date
    1988-10
    
    Metadata
    Show full item record
    Abstract
    The light and electron microscopic features of rectal biopsies from 10 symptomatic patients treated with irradiation for pelvic malignancies are detailed. They are divided into two groups. Group I: biopsies taken during or shortly after the course of irradiation (six patients). Group II: biopsies taken 4 months or more after course completion (four patients). The distinguishing light microscopic features in the first group are epithelial meganucleosis, lack of mitotic activity, and patchy fibroblastic proliferation in the lamina propria. The blood vessels appear normal. In the second group, there are severe vascular changes characterized by narrowing of the arterioles by subintimal fibrosis, telangiectasia of capillaries and post-capillary venules, endothelial degeneration, and platelet thrombi formation. These vascular changes are always associated with severe fibrosis of the lamina propria and crypt distortion. The ultrastructural and light microscopic findings indicate that the cellular epithelial reaction and fibroblastic proliferation antedate the vascular injury, and the latter has no role in the acute phase reaction.
    Citation
    The light and electron microscopic features of early and late phase radiation-induced proctitis. 1988, 83 (10):1140-4 Am. J. Gastroenterol.
    Journal
    American Journal of Gastroenterology
    URI
    http://hdl.handle.net/10541/115191
    PubMed ID
    3421224
    Type
    Article
    Language
    en
    ISSN
    0002-9270
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Acute irradiation proctitis in man: development of eosinophilic crypt abscesses.
    • Authors: Gelfand MD, Tepper M, Katz LA, Binder HJ, Yesner R, Floch MH
    • Issue date: 1968 Mar
    • Proctitis cystica profunda and radiation fibrosis in the rectum of the female Wistar rat after X irradiation: a histopathological study.
    • Authors: Hubmann FH
    • Issue date: 1982 Nov
    • The significance of rectal bleeding after pelvic radiotherapy.
    • Authors: Williams HR, Vlavianos P, Blake P, Dearnaley DP, Tait D, Andreyev HJ
    • Issue date: 2005 May 1
    • Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy.
    • Authors: Kouvaris J, Kouloulias V, Malas E, Antypas C, Kokakis J, Michopoulos S, Matsopoulos G, Vlahos L
    • Issue date: 2003 Mar
    • Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: results of a prospective multicenter study of 166 patients.
    • Authors: Goldner G, Tomicek B, Becker G, Geinitz H, Wachter S, Zimmermann F, Wachter-Gerstner N, Reibenwein J, Glocker S, Bamberg M, Feldmann H, Pötzi R, Molls M, Pötter R
    • Issue date: 2007 Jan 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.