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    Irradiation-induced growth failure.

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    Authors
    Shalet, Stephen M
    Issue Date
    1986-08
    
    Metadata
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    Abstract
    Short stature may complicate the treatment during childhood of brain tumours and, to a lesser extent, ALL. A number of factors may be responsible, including spinal irradiation, malnutrition, recurrent tumour, chemotherapy, precocious puberty and radiation-induced GH deficiency. GH is always the first pituitary hormone to be affected by radiation damage to the hypothalamic-pituitary axis but larger radiation doses may result in panhypopituitarism. Some children retain normal GH responses to certain provocative stimuli, although physiological GH secretion is reduced. Nonetheless, in children suspected of radiation-induced GH deficiency, pharmacological tests of GH secretion remain useful, the ITT being the test of choice because of the marked radiation sensitivity of the GH response to hypoglycaemia. The hypothalamus is more radiosensitive than the pituitary. In many patients with radiation-induced GH deficiency, the damage appears to be at the hypothalamic level resulting in a deficiency of endogenous GRF. Treatment with synthetic GRF may provide an alternative to GH therapy in such children. Finally, there is no evidence to suggest that GH therapy given to a child with radiation-induced GH deficiency might induce a brain tumour recurrence or a relapse of ALL.
    Citation
    Irradiation-induced growth failure. 1986, 15 (3):591-606 Clin Endocrinol Metab
    Journal
    Clinics in Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/115187
    PubMed ID
    2429795
    Type
    Article
    Language
    en
    ISSN
    0300-595X
    Collections
    All Christie Publications

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