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    Testosterone and gonadotrophin profiles in patients on daily or monthly LHRH analogue ICI 118630 (Zoladex) compared with orchiectomy.

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    Authors
    Grant, J
    Ahmed, S Rafeeq
    Shalet, Stephen M
    Costello, C B
    Howell, Anthony
    Blacklock, N
    Affiliation
    Department of Urology, Withington Hospital, Manchester, M21 1AH, UK.
    Issue Date
    1986-10
    
    Metadata
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    Abstract
    Diurnal profiles of circulating gonadotrophins and testosterone have been measured in patients with prostatic carcinoma on long-term treatment with the LHRH agonist analogue ICI 118630, which was administered either by subcutaneous daily injection or monthly injection of the depot preparation. These have been compared with profiles in patients who had undergone orchiectomy. Daily injection of the analogue induced a significant rise in the level of LH but this was not associated with a significant rise in circulating testosterone. There was no diurnal variation of LH or testosterone concentration in patients receiving the depot preparation and this did not differ in patients who were "mid-cycle" compared with those who were "end-cycle". The depot preparation did, however, induce significantly lower circulating levels of testosterone than did daily injection of the analogue and the levels were comparable with those achieved after orchiectomy.
    Citation
    Testosterone and gonadotrophin profiles in patients on daily or monthly LHRH analogue ICI 118630 (Zoladex) compared with orchiectomy. 1986, 58 (5):539-44 Br J Urol
    Journal
    British Journal of Urology
    URI
    http://hdl.handle.net/10541/115178
    DOI
    10.1111/j.1464-410X.1986.tb05463.x
    PubMed ID
    2946356
    Type
    Article
    Language
    en
    ISSN
    0007-1331
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1464-410X.1986.tb05463.x
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