Occurrence of a fetal fibroblast phenotype in familial breast cancer.
MetadataShow full item record
AbstractWe have previously shown that fetal and adult human skin fibroblasts display distinctive migratory phenotypes when cultured on 3-dimensional collagen gels in vitro. In the present study, we have used this information to assess the migratory behavior of fibroblasts obtained from patients with either benign or malignant breast disease, and correlated this with the presence of a family history of breast cancer. We have observed that fibroblasts from 17/34 patients with no previous family history of breast cancer displayed fetal-type behavior in our assay system; in contrast, fibroblasts from 15/16 patients with a positive family history of breast cancer behaved abnormally. This apparently increased probability of expressing a fetal-type migratory phenotype in the patients with a family history is statistically significant (p less than 0.008). Skin fibroblasts obtained from 2 healthy and unaffected first-degree relatives (one male and one female) of patients with a family history of breast cancer also exhibited a fetal-type migratory phenotype.
CitationOccurrence of a fetal fibroblast phenotype in familial breast cancer. 1986, 37 (6):831-6 Int J Cancer
JournalInternational Journal of Cancer
- Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro.
- Authors: Haggie JA, Sellwood RA, Howell A, Birch JM, Schor SL
- Issue date: 1987 Jun 27
- Fibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro.
- Authors: Durning P, Schor SL, Sellwood RA
- Issue date: 1984 Oct 20
- Phenotypic heterogeneity in breast fibroblasts: functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma.
- Authors: Schor AM, Rushton G, Ferguson JE, Howell A, Redford J, Schor SL
- Issue date: 1994 Oct 1
- Fetal dermal fibroblasts retain a hyperactive migratory and contractile phenotype under 2-and 3-dimensional constraints compared to normal adult fibroblasts.
- Authors: Sandulache VC, Parekh A, Dohar JE, Hebda PA
- Issue date: 2007 Nov
- Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels.
- Authors: Schor SL, Schor AM, Durning P, Rushton G
- Issue date: 1985 Feb