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    Modulation of smooth muscle cell behaviour by platelet-derived factors and the extracellular matrix.

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    Authors
    Wren, Fiona E
    Schor, Ana M
    Schor, Seth L
    Grant, M E
    Affiliation
    Cancer Research Campaign Laboratory of Medical Oncology, Christie Hospital Radium Institute, Manchester, M20 9BX, England.
    Issue Date
    1986-05
    
    Metadata
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    Abstract
    We have studied the combined effects of platelet-derived soluble factors and three types of macromolecular substrata on the proliferation and migration of smooth muscle cells in vitro. Bovine aortic smooth muscle cells were plated onto three-dimensional gels of type I collagen or onto cell-free extracellular matrices deposited on such gels by either bovine aortic endothelial cells or smooth muscle cells. The cells were cultured in the presence of whole-blood serum (WBS) or platelet-poor plasma (PPP). Smooth muscle cell proliferation on type I collagen gels was dependent on the presence of platelet-derived factors, i.e. the cells proliferated in the presence of WBS but not in PPP. In contrast, cell proliferation on the extracellular matrices occurred at the same rate in PPP and WBS. Smooth muscle cells plated onto collagen gels rapidly migrated down into the gel matrix; the percentage of cells migrating was inversely proportional to cell density. The presence of extracellular matrices did not alter the rate of cell migration into the underlying gel matrix. Irrespective of the substratum used, smooth muscle cell migration was independent of platelet-derived or plasma factors and occurred in the absence of proliferation. These results indicate that possible chemotactic, chemokinetic, and/or mitogenic factors produced by the vascular cells and deposited within the extracellular matrix may play an important role in modulating smooth muscle cell behaviour in the vascular wall.
    Citation
    Modulation of smooth muscle cell behaviour by platelet-derived factors and the extracellular matrix. 1986, 127 (2):297-302 J Cell Physiol
    Journal
    Journal of Cellular Physiology
    URI
    http://hdl.handle.net/10541/115153
    DOI
    10.1002/jcp.1041270217
    PubMed ID
    3700485
    Type
    Article
    Language
    en
    ISSN
    0021-9541
    EISSN
    1097-4652
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.1041270217
    Scopus Count
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