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dc.contributor.authorBenstead, K
dc.contributor.authorCowie, V
dc.contributor.authorBlair, Val
dc.contributor.authorHunter, Robin D
dc.date.accessioned2010-11-08T16:02:17Z
dc.date.available2010-11-08T16:02:17Z
dc.date.issued1986-04
dc.identifier.citationStage III carcinoma of cervix. The importance of increasing age and extent of parametrial infiltration. 1986, 5 (4):271-6 Radiother Oncolen
dc.identifier.issn0167-8140
dc.identifier.pmid3726165
dc.identifier.doi10.1016/S0167-8140(86)80175-X
dc.identifier.urihttp://hdl.handle.net/10541/115092
dc.description.abstractThe relative importance of a number of potential prognostic factors was analysed for a sequential group of 296 patients with stage III carcinoma of the cervix who had been treated in a mature prospective clinical trial. Using a log-rank analysis of survival curves generated by the life-table method increasing age (p = 0.05) and extent of parametrial infiltration (p = 0.001) were found to be significantly related to prognosis. These two factors were further demonstrated to be independent variables and, of the two, parametrial extension (p = 0.002) was more significant than increased age (p = 0.035). Involvement of the lower third of the vagina, the presence of bullous oedema and the histological differentiation of the disease were not prognostically significant in this study. It is suggested that tumour volume as defined by extent of parametrial infiltration is a sufficiently good prognostic factor to be incorporated into a revised staging system.
dc.language.isoenen
dc.subjectCancer Stagingen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdenocarcinoma
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshBrachytherapy
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshCarcinoma, Transitional Cell
dc.subject.meshCervix Uteri
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshRadiotherapy Dosage
dc.subject.meshUterine Cervical Neoplasms
dc.subject.meshUterus
dc.subject.meshVagina
dc.titleStage III carcinoma of cervix. The importance of increasing age and extent of parametrial infiltration.en
dc.typeArticleen
dc.identifier.eissn1879-0887
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractThe relative importance of a number of potential prognostic factors was analysed for a sequential group of 296 patients with stage III carcinoma of the cervix who had been treated in a mature prospective clinical trial. Using a log-rank analysis of survival curves generated by the life-table method increasing age (p = 0.05) and extent of parametrial infiltration (p = 0.001) were found to be significantly related to prognosis. These two factors were further demonstrated to be independent variables and, of the two, parametrial extension (p = 0.002) was more significant than increased age (p = 0.035). Involvement of the lower third of the vagina, the presence of bullous oedema and the histological differentiation of the disease were not prognostically significant in this study. It is suggested that tumour volume as defined by extent of parametrial infiltration is a sufficiently good prognostic factor to be incorporated into a revised staging system.


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