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The reduction of anti-tumour diaziridinyl benzoquinones.

dc.contributor.authorButler, John
dc.contributor.authorHoey, Brigid M
dc.contributor.authorLea, J S
dc.date.accessioned2010-11-08T12:34:55Z
dc.date.available2010-11-08T12:34:55Z
dc.date.issued1987-08-13
dc.identifier.citationThe reduction of anti-tumour diaziridinyl benzoquinones. 1987, 925 (2):144-9 Biochim Biophys Actaen
dc.identifier.issn0006-3002
dc.identifier.pmid3040109
dc.identifier.doi10.1016/0304-4165(87)90103-6
dc.identifier.urihttp://hdl.handle.net/10541/114969
dc.description.abstractThe properties of the semiquinone radicals produced for 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ), have been investigated. AZQ semiquinone radicals can be produced from the reduction of AZQ by superoxide radicals, whereas BZQ semiquinone radicals are unstable in the presence of oxygen. The one-electron reduction potentials of the couples Q/Q-. at pH 7.0 were determined as -70 +/- 10 mV for AZQ and -376 +/- 15 mV for BZQ. The difference in these potentials is explained. As a consequence of ESR studies on the enzymatically produced radicals, we have considered the factors which determine the detection of ESR signals for reduced quinones produced in a biological system.
dc.language.isoenen
dc.subjectAnticancerous Agentsen
dc.subject.meshAntineoplastic Agents
dc.subject.meshAziridines
dc.subject.meshAzirines
dc.subject.meshBenzoquinones
dc.subject.meshCross-Linking Reagents
dc.subject.meshElectron Spin Resonance Spectroscopy
dc.subject.meshFree Radicals
dc.subject.meshOxidation-Reduction
dc.subject.meshQuinones
dc.subject.meshSolubility
dc.subject.meshSpectrum Analysis
dc.titleThe reduction of anti-tumour diaziridinyl benzoquinones.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biophysical Chemistry, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, U.K.en
dc.identifier.journalBiochimica et Biophysica Actaen
html.description.abstractThe properties of the semiquinone radicals produced for 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ), have been investigated. AZQ semiquinone radicals can be produced from the reduction of AZQ by superoxide radicals, whereas BZQ semiquinone radicals are unstable in the presence of oxygen. The one-electron reduction potentials of the couples Q/Q-. at pH 7.0 were determined as -70 +/- 10 mV for AZQ and -376 +/- 15 mV for BZQ. The difference in these potentials is explained. As a consequence of ESR studies on the enzymatically produced radicals, we have considered the factors which determine the detection of ESR signals for reduced quinones produced in a biological system.


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