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dc.contributor.authorMolineux, Graham
dc.contributor.authorTesta, Nydia G
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorSchofield, Raymond
dc.date.accessioned2010-11-08T12:30:35Z
dc.date.available2010-11-08T12:30:35Z
dc.date.issued1987-10
dc.identifier.citationThe radiation sensitivity of the haemopoietic microenvironment--effect of dose rate on ectopic ossicle formation. 1987, 10 (2):157-61 Radiother Oncolen
dc.identifier.issn0167-8140
dc.identifier.pmid3321200
dc.identifier.doi10.1016/S0167-8140(87)80058-0
dc.identifier.urihttp://hdl.handle.net/10541/114968
dc.description.abstractThe haemopoietic microenvironment (HM) consists of a complex mixture of cellular types and extra-cellular matrix. It is essential for prolonged haemopoiesis in both the normal situation and after bone marrow transplantation. The competence of the HM can be assessed by ectopic grafting of femoral marrow. A complete haemopoietic organ develops at the site of implantation. Stem cells (CFU-S) which inhabit the ossicle formed after ectopic implantation can be measured, to assess the function of the engrafted HM to support haemopoiesis. Using this functional endpoint we have examined the radiation sensitivity of the HM at both high and low dose rates, and conclude that high doses of gamma-irradiation delivered at 4 Gy/min or 0.016 Gy/min have widely different effects on the HM, the former proving much more damaging than the latter.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectHaematopoietic Systemen
dc.subject.meshAnimals
dc.subject.meshBone Marrow
dc.subject.meshBone Marrow Transplantation
dc.subject.meshColony-Forming Units Assay
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshGamma Rays
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHematopoietic System
dc.subject.meshKidney
dc.subject.meshMice
dc.subject.meshOsteogenesis
dc.subject.meshRadiation Tolerance
dc.subject.meshWhole-Body Irradiation
dc.titleThe radiation sensitivity of the haemopoietic microenvironment--effect of dose rate on ectopic ossicle formation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, U.K.en
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractThe haemopoietic microenvironment (HM) consists of a complex mixture of cellular types and extra-cellular matrix. It is essential for prolonged haemopoiesis in both the normal situation and after bone marrow transplantation. The competence of the HM can be assessed by ectopic grafting of femoral marrow. A complete haemopoietic organ develops at the site of implantation. Stem cells (CFU-S) which inhabit the ossicle formed after ectopic implantation can be measured, to assess the function of the engrafted HM to support haemopoiesis. Using this functional endpoint we have examined the radiation sensitivity of the HM at both high and low dose rates, and conclude that high doses of gamma-irradiation delivered at 4 Gy/min or 0.016 Gy/min have widely different effects on the HM, the former proving much more damaging than the latter.


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