The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
| dc.contributor.author | Aruoma, O I | |
| dc.contributor.author | Wasil, M | |
| dc.contributor.author | Halliwell, B | |
| dc.contributor.author | Hoey, Brigid M | |
| dc.contributor.author | Butler, John | |
| dc.date.accessioned | 2010-11-08T12:11:02Z | |
| dc.date.available | 2010-11-08T12:11:02Z | |
| dc.date.issued | 1987-11-01 | |
| dc.identifier.citation | The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? 1987, 36 (21):3739-42 Biochem Pharmacol | en |
| dc.identifier.issn | 0006-2952 | |
| dc.identifier.pmid | 2890355 | |
| dc.identifier.doi | 10.1016/0006-2952(87)90028-1 | |
| dc.identifier.uri | http://hdl.handle.net/10541/114948 | |
| dc.description.abstract | Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Aminosalicylic Acids | |
| dc.subject.mesh | Anti-Inflammatory Agents | |
| dc.subject.mesh | Hydroxides | |
| dc.subject.mesh | Hydroxyl Radical | |
| dc.subject.mesh | Hypochlorous Acid | |
| dc.subject.mesh | Mesalamine | |
| dc.subject.mesh | Oxidation-Reduction | |
| dc.subject.mesh | Sulfanilamides | |
| dc.subject.mesh | Sulfapyridine | |
| dc.subject.mesh | Sulfasalazine | |
| dc.title | The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Biochemistry, King's College, London, U.K. | en |
| dc.identifier.journal | Biochemical Pharmacology | en |
| html.description.abstract | Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites. |