The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
Affiliation
Department of Biochemistry, King's College, London, U.K.Issue Date
1987-11-01
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Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites.Citation
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? 1987, 36 (21):3739-42 Biochem PharmacolJournal
Biochemical PharmacologyDOI
10.1016/0006-2952(87)90028-1PubMed ID
2890355Type
ArticleLanguage
enISSN
0006-2952ae974a485f413a2113503eed53cd6c53
10.1016/0006-2952(87)90028-1
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