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    Radiobiology and stathmokinetics of intestinal crypts associated with patches of Peyer.

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    Authors
    Maunda, K K Y
    Moore, James V
    Issue Date
    1987-02
    
    Metadata
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    Abstract
    The stathmokinetics and radiobiology of intestinal crypts directly adjoining the lymphoid patches of Peyer, have been compared with those of non-patch-associated crypts. Patch crypts contain an additional one to two rings of cells, the Mitotic Index for the whole crypt is higher than in non-patch crypts, and the apparent cell cycle time is insignificantly lower. Using single and split doses of gamma-rays, dose-survival curves were obtained for whole intestinal crypts, from which single-cell survival curves were derived for the clonogenic cells of the crypt. For a single-hit, multitarget, model, the extrapolation numbers of the cell survival curves for patch and non-patch crypts were the same (approximately 35) but the final D0 for cells of the patch crypts was significantly higher (2.1 versus 1.7 Gy). A linear-quadratic fit gave a similar ratio of alpha/beta (approximately 10) for the two curves. For a given level of crypt depletion, the number of clonogenic cells per crypt derived by the use of equal split doses of radiation, was the same for patch and non-patch crypts. This number is a function of the dose regime employed: the higher the level of crypt depletion, the higher the derived number of cells (range 10 to 45, for non-patch crypts).
    Citation
    Radiobiology and stathmokinetics of intestinal crypts associated with patches of Peyer. 1987, 51 (2):255-64 Int. J Radiat Biol Relat Stud Phys Chem Med
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/114944
    DOI
    10.1080/09553008714550751
    PubMed ID
    3493990
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553008714550751
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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