Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?
| dc.contributor.author | Butler, John | |
| dc.contributor.author | Hoey, Brigid M | |
| dc.date.accessioned | 2010-11-06T12:29:05Z | |
| dc.date.available | 2010-11-06T12:29:05Z | |
| dc.date.issued | 1987-06 | |
| dc.identifier.citation | Are reduced quinones necessarily involved in the antitumour activity of quinone drugs? 1987, 8:53-9 Br. J Cancer Suppl | en |
| dc.identifier.issn | 0306-9443 | |
| dc.identifier.pmid | 3307874 | |
| dc.identifier.uri | http://hdl.handle.net/10541/114867 | |
| dc.description.abstract | Several studies have shown that the antitumour quinones, adriamycin, mitomycin C, mitozantrone and 3,6-diaziridinyl-2,5-bis (carboethoxyamino)-1,4-benzoquinone (AZQ) can form semiquinone radicals in vitro. The biophysical chemistry data for these reactions and the properties of the radical quinones are presented together with the proposed mechanisms for cytotoxicity. An attempt has been made to correlate the available in vitro data for the quinones with each other and with the available in vivo data. As a consequence of these correlations a number of conclusions have been proposed regarding the techniques of investigation and the evidence for the role of reduced quinones in antitumour activity. | |
| dc.language.iso | en | en |
| dc.subject | Anticancerous Agents | en |
| dc.subject.mesh | Antineoplastic Agents | |
| dc.subject.mesh | Cell Survival | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Oxygen Consumption | |
| dc.subject.mesh | Quinone Reductases | |
| dc.subject.mesh | Quinones | |
| dc.title | Are reduced quinones necessarily involved in the antitumour activity of quinone drugs? | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Biophysical Chemistry, Christie Hospital & Holt Radium Institute, Manchester, UK. | en |
| dc.identifier.journal | British Journal of Cancer Supplement | en |
| html.description.abstract | Several studies have shown that the antitumour quinones, adriamycin, mitomycin C, mitozantrone and 3,6-diaziridinyl-2,5-bis (carboethoxyamino)-1,4-benzoquinone (AZQ) can form semiquinone radicals in vitro. The biophysical chemistry data for these reactions and the properties of the radical quinones are presented together with the proposed mechanisms for cytotoxicity. An attempt has been made to correlate the available in vitro data for the quinones with each other and with the available in vivo data. As a consequence of these correlations a number of conclusions have been proposed regarding the techniques of investigation and the evidence for the role of reduced quinones in antitumour activity. |