Show simple item record

dc.contributor.authorArnold, F
dc.contributor.authorWest, David C
dc.contributor.authorKumar, Shant
dc.date.accessioned2010-11-04T10:16:32Z
dc.date.available2010-11-04T10:16:32Z
dc.date.issued1987-08
dc.identifier.citationWound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization. 1987, 68 (4):569-74 Br J Exp Patholen
dc.identifier.issn0007-1021
dc.identifier.pmid2443156
dc.identifier.urihttp://hdl.handle.net/10541/114671
dc.description.abstractAngiogenic factors prepared from rat Walker 256 mammary carcinoma, (TAF) and activated mouse peritoneal macrophages (MAF), were tested for their ability to stimulate vascularization during healing. They were applied to one of a pair of bilaterally symmetrical, autologous, isotopic, full thickness skin grafts in mice. Blood flow to treated and untreated graft pairs was compared by their uptake of injected 86Rb Cl, at 3 and 7 days after grafting. No difference was detected after treatment with either agent. We conclude that while angiogenic factors are important in vascularization during healing, this normally occurs at a near maximal rate and cannot be further enhanced.
dc.language.isoenen
dc.subject.meshAngiogenesis Inducing Agents
dc.subject.meshAnimals
dc.subject.meshCarcinoma 256, Walker
dc.subject.meshGrowth Substances
dc.subject.meshMacrophages
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshNeovascularization, Pathologic
dc.subject.meshRats
dc.subject.meshRegional Blood Flow
dc.subject.meshSkin
dc.subject.meshSkin Transplantation
dc.subject.meshWound Healing
dc.titleWound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization.en
dc.typeArticleen
dc.contributor.departmentClinical Research Laboratories, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Experimental Pathologyen
html.description.abstractAngiogenic factors prepared from rat Walker 256 mammary carcinoma, (TAF) and activated mouse peritoneal macrophages (MAF), were tested for their ability to stimulate vascularization during healing. They were applied to one of a pair of bilaterally symmetrical, autologous, isotopic, full thickness skin grafts in mice. Blood flow to treated and untreated graft pairs was compared by their uptake of injected 86Rb Cl, at 3 and 7 days after grafting. No difference was detected after treatment with either agent. We conclude that while angiogenic factors are important in vascularization during healing, this normally occurs at a near maximal rate and cannot be further enhanced.


This item appears in the following Collection(s)

Show simple item record