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    Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization.

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    Authors
    Arnold, F
    West, David C
    Kumar, Shant
    Affiliation
    Clinical Research Laboratories, Christie Hospital, Manchester, UK.
    Issue Date
    1987-08
    
    Metadata
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    Abstract
    Angiogenic factors prepared from rat Walker 256 mammary carcinoma, (TAF) and activated mouse peritoneal macrophages (MAF), were tested for their ability to stimulate vascularization during healing. They were applied to one of a pair of bilaterally symmetrical, autologous, isotopic, full thickness skin grafts in mice. Blood flow to treated and untreated graft pairs was compared by their uptake of injected 86Rb Cl, at 3 and 7 days after grafting. No difference was detected after treatment with either agent. We conclude that while angiogenic factors are important in vascularization during healing, this normally occurs at a near maximal rate and cannot be further enhanced.
    Citation
    Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization. 1987, 68 (4):569-74 Br J Exp Pathol
    Journal
    British Journal of Experimental Pathology
    URI
    http://hdl.handle.net/10541/114671
    PubMed ID
    2443156
    Type
    Article
    Language
    en
    ISSN
    0007-1021
    Collections
    All Christie Publications

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