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dc.contributor.authorKumar, Shant
dc.contributor.authorMarsden, Henry B
dc.contributor.authorJasani, B
dc.contributor.authorKumar, Patricia
dc.date.accessioned2010-11-04T10:13:07Z
dc.date.available2010-11-04T10:13:07Z
dc.date.issued1987-12
dc.identifier.citationStudy of childhood renal tumours using a monoclonal antibody to Tamm-Horsfall protein. 1987, 40 (12):1456-62 J. Clin. Pathol.en
dc.identifier.issn0021-9746
dc.identifier.pmid3429675
dc.identifier.doi10.1136/jcp.40.12.1456
dc.identifier.urihttp://hdl.handle.net/10541/114669
dc.description.abstractA monoclonal antibody to Tamm-Horsfall glycoprotein was used for the immuno-localization of Tamm-Horsfall protein in formalin fixed, paraffin embedded tissue sections of childhood renal tumours, normal children's kidneys, and human fetal kidneys. The procedure was a dinitrophenyl hapten sandwich staining method. The antibody, diluted 1/100,000, gave a very strong and specific staining of the loop of Henle and distal tubules of normal and fetal kidneys. No staining was seen in Wilms' tumour, mesoblastic nephroma, and bone metastasizing renal tumour of childhood. In contrast, two of seven renal carcinomas and three of four rhabdoid renal tumours were positive for Tamm-Horsfall protein.
dc.language.isoenen
dc.subjectKidney Canceren
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshChild
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshKidney
dc.subject.meshKidney Neoplasms
dc.subject.meshMucoproteins
dc.titleStudy of childhood renal tumours using a monoclonal antibody to Tamm-Horsfall protein.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen
refterms.dateFOA2020-06-18T15:16:02Z
html.description.abstractA monoclonal antibody to Tamm-Horsfall glycoprotein was used for the immuno-localization of Tamm-Horsfall protein in formalin fixed, paraffin embedded tissue sections of childhood renal tumours, normal children's kidneys, and human fetal kidneys. The procedure was a dinitrophenyl hapten sandwich staining method. The antibody, diluted 1/100,000, gave a very strong and specific staining of the loop of Henle and distal tubules of normal and fetal kidneys. No staining was seen in Wilms' tumour, mesoblastic nephroma, and bone metastasizing renal tumour of childhood. In contrast, two of seven renal carcinomas and three of four rhabdoid renal tumours were positive for Tamm-Horsfall protein.


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