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dc.contributor.authorCuzick, J
dc.contributor.authorStewart, H
dc.contributor.authorPeto, R
dc.contributor.authorBaum, M
dc.contributor.authorFisher, B
dc.contributor.authorHost, H
dc.contributor.authorLythgoe, J P
dc.contributor.authorRibeiro, G
dc.contributor.authorScheurlen, H
dc.contributor.authorWallgren, A
dc.date.accessioned2010-11-03T16:50:47Z
dc.date.available2010-11-03T16:50:47Z
dc.date.issued1987-01
dc.identifier.citationOverview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. 1987, 71 (1):15-29 Cancer Treat Repen
dc.identifier.issn0361-5960
dc.identifier.pmid2856861
dc.identifier.urihttp://hdl.handle.net/10541/114639
dc.description.abstractAn overview of the mortality results of the mature trials in which radiotherapy was a randomized option after simple or radical mastectomy is presented. The principal aim of the overview was to study long-term survival, and recent trials, often including chemotherapy options, have not been included. A total of 7941 patients were entered into these trials and 4148 deaths occurred. No differences were found in survival in the first 10 years of follow-up, in trials employing either radical mastectomy or simple mastectomy. Follow-up information after 10 years came mostly from trials employing radical mastectomy with or without irradiation, and in these trials a significant excess of deaths was observed among patients given radiotherapy (P less than 0.001, all trials; P = 0.002, radical mastectomy trials only). Further data collection will be necessary to determine which causes of death are elevated.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms
dc.subject.meshClinical Trials as Topic
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMastectomy
dc.subject.meshMiddle Aged
dc.subject.meshRandom Allocation
dc.subject.meshResearch Design
dc.subject.meshRisk
dc.titleOverview of randomized trials of postoperative adjuvant radiotherapy in breast cancer.en
dc.typeArticleen
dc.identifier.journalCancer Treatment Reportsen
html.description.abstractAn overview of the mortality results of the mature trials in which radiotherapy was a randomized option after simple or radical mastectomy is presented. The principal aim of the overview was to study long-term survival, and recent trials, often including chemotherapy options, have not been included. A total of 7941 patients were entered into these trials and 4148 deaths occurred. No differences were found in survival in the first 10 years of follow-up, in trials employing either radical mastectomy or simple mastectomy. Follow-up information after 10 years came mostly from trials employing radical mastectomy with or without irradiation, and in these trials a significant excess of deaths was observed among patients given radiotherapy (P less than 0.001, all trials; P = 0.002, radical mastectomy trials only). Further data collection will be necessary to determine which causes of death are elevated.


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