Infiltrating lobular carcinoma of the breast: response to endocrine therapy and survival.
Affiliation
Cancer Research Campaign Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.Issue Date
1987-07
Metadata
Show full item recordAbstract
The records of 480 patients who received systemic therapy for advanced breast cancer in the University Hospital of South Manchester from 1975 to 1983 were examined. There were 264 with infiltrating duct carcinomas (IDC) and 33 with infiltrating lobular carcinomas (ILC) for whom the response to endocrine therapy was known. There were 92 responses (35%) among the IDC patients and 9 (27%) among the ILC patients. Sixty-seven per cent of IDC patients tested had steroid hormone receptor positive tumours compared to 90% for ILC (P less than 0.001). Comparison of survival from diagnosis, disease free interval and survival from relapse showed no significant differences between the two groups. Thus despite almost all ILC patients having hormone receptor positive tumours their survival was similar to that of IDC patients. This appears to be due to a lower than expected response rate to endocrine therapy. This is a further indication of the different biological characteristics of these two histological sub-types of breast carcinoma.Citation
Infiltrating lobular carcinoma of the breast: response to endocrine therapy and survival. 1987, 23 (7):979-82 Eur J Cancer Clin OncolJournal
European Journal of Cancer & Clinical OncologyDOI
10.1016/0277-5379(87)90344-0PubMed ID
2822427Type
ArticleLanguage
enISSN
0277-5379ae974a485f413a2113503eed53cd6c53
10.1016/0277-5379(87)90344-0
Scopus Count
Collections
Related articles
- Relative effectiveness of adjuvant chemotherapy for invasive lobular compared with invasive ductal carcinoma of the breast.
- Authors: Marmor S, Hui JYC, Huang JL, Kizy S, Beckwith H, Blaes AH, Rueth NM, Tuttle TM
- Issue date: 2017 Aug 15
- Influence of semi-quantitative oestrogen receptor expression on adjuvant endocrine therapy efficacy in ductal and lobular breast cancer - a TEAM study analysis.
- Authors: van de Water W, Fontein DB, van Nes JG, Bartlett JM, Hille ET, Putter H, Robson T, Liefers GJ, Roumen RM, Seynaeve C, Dirix LY, Paridaens R, Kranenbarg EM, Nortier JW, van de Velde CJ
- Issue date: 2013 Jan
- Specific sites of metastases in invasive lobular carcinoma: a retrospective cohort study of metastatic breast cancer.
- Authors: Inoue M, Nakagomi H, Nakada H, Furuya K, Ikegame K, Watanabe H, Omata M, Oyama T
- Issue date: 2017 Sep
- Infiltrating lobular carcinoma--a comparison of diagnosis, management and outcome with infiltrating duct carcinoma.
- Authors: Molland JG, Donnellan M, Janu NC, Carmalt HL, Kennedy CW, Gillett DJ
- Issue date: 2004 Oct
- HER2-Positive Lobular Versus Ductal Carcinoma of the Breast: Pattern of First Recurrence and Molecular Insights.
- Authors: Da Ros L, Moretti A, Querzoli P, Pedriali M, Lupini L, Bassi C, Carcoforo P, Negrini M, Frassoldati A
- Issue date: 2018 Oct