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Malignant melanoma in families of children with osteosarcoma, chondrosarcoma, and adrenal cortical carcinoma.

dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorMarsden, Henry B
dc.contributor.authorHarris, Martin
dc.date.accessioned2010-11-03T15:59:13Z
dc.date.available2010-11-03T15:59:13Z
dc.date.issued1987-11
dc.identifier.citationMalignant melanoma in families of children with osteosarcoma, chondrosarcoma, and adrenal cortical carcinoma. 1987, 24 (11):664-8 J. Med. Genet.en
dc.identifier.issn0022-2593
dc.identifier.pmid3480957
dc.identifier.doi10.1136/jmg.24.11.664
dc.identifier.urihttp://hdl.handle.net/10541/114521
dc.description.abstractSeven cases of malignant melanoma in the close relatives of children with osteosarcoma and chondrosarcoma are described. The association between certain childhood malignancies (adrenal cortical carcinoma, osteosarcoma, chondrosarcoma, retinoblastoma) and malignant melanoma is discussed and it is proposed that in certain families malignant melanoma may be another manifestation of the same gene defect which results in susceptibility to tumours characteristic of the SBLA cancer family syndrome.
dc.language.isoenen
dc.subjectAdrenal Cortex Canceren
dc.subjectBone Canceren
dc.subjectSkin Canceren
dc.subject.meshAdolescent
dc.subject.meshAdrenal Cortex Neoplasms
dc.subject.meshBone Neoplasms
dc.subject.meshChild
dc.subject.meshChondrosarcoma
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMelanoma
dc.subject.meshOsteosarcoma
dc.subject.meshPedigree
dc.subject.meshRisk Factors
dc.subject.meshSkin Neoplasms
dc.subject.meshSyndrome
dc.titleMalignant melanoma in families of children with osteosarcoma, chondrosarcoma, and adrenal cortical carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology and Social Oncology, Christie Hospital and Holt Radium Institute, Manchester.en
dc.identifier.journalJournal of Medical Geneticsen
html.description.abstractSeven cases of malignant melanoma in the close relatives of children with osteosarcoma and chondrosarcoma are described. The association between certain childhood malignancies (adrenal cortical carcinoma, osteosarcoma, chondrosarcoma, retinoblastoma) and malignant melanoma is discussed and it is proposed that in certain families malignant melanoma may be another manifestation of the same gene defect which results in susceptibility to tumours characteristic of the SBLA cancer family syndrome.


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