Haemopoietic growth factors: their relevance in osteoclast formation and function.
Affiliation
Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Withington, Manchester, UK.Issue Date
1988
Metadata
Show full item recordAbstract
The major recent advance in our knowledge of the haemopoietic system has been the purification and characterization of a family of haemopoietic growth factors, and their availability in recombinant form. In the bone marrow the sequences of differentiation and proliferation leading to the production of mature cells that these factors regulate may be determined by the relative availability of the factors in microenvironmental domains. The observation that growth factor-producing cells and haemopoietic progenitor cells are not evenly distributed in the bone marrow leads us to expect that the overall effect of growth factors (and other regulatory molecules) on the production and function of macrophages and osteoclasts may differ when in vivo or in vitro assays are used as end-points and, in the latter case, when whole marrow or purified cell populations are tested. The availability of an in vitro assay in which osteoclast-like cells are generated will allow these concepts to be tested.Citation
Haemopoietic growth factors: their relevance in osteoclast formation and function. 1988, 136:257-74 Ciba Found. Symp.Journal
Ciba Foundation SymposiumPubMed ID
3068014Type
ArticleLanguage
enISSN
0300-5208Collections
Related articles
- Haemopoietic growth factors.
- Authors: Dexter TM
- Issue date: 1989 Apr
- Haemopoietic growth factor control of normal and neoplastic cellular proliferation.
- Authors: Burgess AW, Cebon J, Smith S
- Issue date: 1989
- Cell surface heparan sulphate implicated in haemopoietic growth factor signalling.
- Authors: Burgess AW
- Issue date: 1988 Sep
- Haemopoietic growth factors 1.
- Authors: Metcalf D
- Issue date: 1989 Apr 15
- Haemopoietic growth factors.
- Authors: Devereux S, Linch D
- Issue date: 1990 Jun