Persistent dose-dependent increases in cycling of haemopoietic precursor cells after irradiation.
| dc.contributor.author | Tejero, C | |
| dc.contributor.author | Hendry, Jolyon H | |
| dc.contributor.author | Testa, Nydia G | |
| dc.date.accessioned | 2010-11-03T11:04:22Z | |
| dc.date.available | 2010-11-03T11:04:22Z | |
| dc.date.issued | 1988-05 | |
| dc.identifier.citation | Persistent dose-dependent increases in cycling of haemopoietic precursor cells after irradiation. 1988, 21 (3):201-4 Cell Tissue Kinet | en |
| dc.identifier.issn | 0008-8730 | |
| dc.identifier.pmid | 3224367 | |
| dc.identifier.uri | http://hdl.handle.net/10541/114436 | |
| dc.description.abstract | Between 3 weeks and 36 months after irradiation of mice, there was a dose-dependent increased level of cycling in haemopoietic stem cells (CFU-S) and in granulocyte-macrophage precursor cells (GM-CFC). For CFU-S the percentage kill measured using the thymidine suicide technique increased from about 10% in controls to a high and persistent average level of about 45% after 10 Gy gamma-rays, and for GM-CFC the increase was from about 30% to about 50%. | |
| dc.language.iso | en | en |
| dc.subject | Haematopoietic Stem Cells | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Colony-Forming Units Assay | |
| dc.subject.mesh | Dose-Response Relationship, Radiation | |
| dc.subject.mesh | Gamma Rays | |
| dc.subject.mesh | Granulocytes | |
| dc.subject.mesh | Hematopoietic Stem Cells | |
| dc.subject.mesh | Macrophages | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Spleen | |
| dc.title | Persistent dose-dependent increases in cycling of haemopoietic precursor cells after irradiation. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Manchester, U.K. | en |
| dc.identifier.journal | Cell and Tissue Kinetics | en |
| html.description.abstract | Between 3 weeks and 36 months after irradiation of mice, there was a dose-dependent increased level of cycling in haemopoietic stem cells (CFU-S) and in granulocyte-macrophage precursor cells (GM-CFC). For CFU-S the percentage kill measured using the thymidine suicide technique increased from about 10% in controls to a high and persistent average level of about 45% after 10 Gy gamma-rays, and for GM-CFC the increase was from about 30% to about 50%. |