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    Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems.

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    Authors
    Littler, Edward
    Arrand, John R
    Affiliation
    Department of Molecular Biology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, United Kingdom.
    Issue Date
    1988-10
    
    Metadata
    Show full item record
    Abstract
    The establishment of mammalian and procaryotic systems which express the Epstein-Barr virus (EBV) thymidine kinase (TK) has been reported previously (E. Littler, J. Zeuthen, A. A. McBride, E. Trøst-Sørensen, K. L. Powell, J. E. Walsh-Arrand, and J. R. Arrand, EMBO J. 5:1959-1966, 1986). The EBV TK activity expressed in both of these systems was characterized by in vitro assays and found to resemble that of the herpes simplex virus TK both in its broad range of nucleoside and nucleotide utilization and also in its ability to accept antiviral nucleoside analogs as substrates. Further results are presented which suggest that these in vitro systems may prove suitable for studying the potential anti-EBV activity of other candidate antiviral compounds.
    Citation
    Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems. 1988, 62 (10):3892-5 J. Virol.
    Journal
    Journal of Virology
    URI
    http://hdl.handle.net/10541/114430
    PubMed ID
    2843685
    Type
    Article
    Language
    en
    ISSN
    0022-538X
    Collections
    All Paterson Institute for Cancer Research

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