The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow.
| dc.contributor.author | Gallini, R | |
| dc.contributor.author | Hendry, Jolyon H | |
| dc.contributor.author | Molineux, Graham | |
| dc.contributor.author | Testa, Nydia G | |
| dc.date.accessioned | 2010-11-02T17:54:03Z | |
| dc.date.available | 2010-11-02T17:54:03Z | |
| dc.date.issued | 1988-09 | |
| dc.identifier.citation | The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow. 1988, 115 (3):481-7 Radiat. Res. | en |
| dc.identifier.issn | 0033-7587 | |
| dc.identifier.pmid | 3174931 | |
| dc.identifier.uri | http://hdl.handle.net/10541/114383 | |
| dc.description.abstract | Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis. | |
| dc.language.iso | en | en |
| dc.subject | Haematopoietic Stem Cells | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Bone Marrow | |
| dc.subject.mesh | Bone Marrow Cells | |
| dc.subject.mesh | Cell Survival | |
| dc.subject.mesh | Cesium Radioisotopes | |
| dc.subject.mesh | Cobalt Radioisotopes | |
| dc.subject.mesh | Dose-Response Relationship, Radiation | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Gamma Rays | |
| dc.subject.mesh | Granulocytes | |
| dc.subject.mesh | Hematopoietic Stem Cells | |
| dc.subject.mesh | Macrophages | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Mice | |
| dc.title | The effect of low dose rate on recovery of hemopoietic and stromal progenitor cells in gamma-irradiated mouse bone marrow. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom. | en |
| dc.identifier.journal | Radiation Research | en |
| html.description.abstract | Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at greater than 0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis. |