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    The lack of correlation between toxicity and free radical formation of two diaziridinyl benzoquinones.

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    Authors
    Lea, J S
    Garner, H J
    Butler, John
    Hoey, Brigid M
    Ward, Timothy H
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital, Holt Radium Institute, Manchester, U.K.
    Issue Date
    1988-05-15
    
    Metadata
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    Abstract
    L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones, 2,5-bis(carboethoxyamino)3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ). BZQ showed a high level of toxicity in both cell lines, but no ESR signal was detectable, while AZQ readily produced an ESR signal but much lower cytotoxicity was observed, particularly in L1210 cells. The rate of superoxide formation was measured for each drug. The results demonstrate that cell killing and free radical production do not necessarily concur.
    Citation
    The lack of correlation between toxicity and free radical formation of two diaziridinyl benzoquinones. 1988, 37 (10):2023-5 Biochem. Pharmacol.
    Journal
    Biochemical Pharmacology
    URI
    http://hdl.handle.net/10541/114363
    DOI
    10.1016/0006-2952(88)90551-5
    PubMed ID
    2837220
    Type
    Article
    Language
    en
    ISSN
    0006-2952
    ae974a485f413a2113503eed53cd6c53
    10.1016/0006-2952(88)90551-5
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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