Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA.
AffiliationDepartment of Otolaryngology, Manchester Royal Infirmary, Christie Hospital and Holt Radium Institute.
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AbstractA case of laryngeal squamous papilloma in the early stages of development showed histological features suggestive of virus infection. Five years later positive evidence of HPV-6 infection was obtained at a time when the lesion had developed into a squamous cell carcinoma. It is concluded that this case represents a complete example of the virus to papilloma to carcinoma sequence, and as far as is known, is the first reported case of its kind in the larynx.
CitationMalignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA. 1988, 41 (3):280-3 J. Clin. Pathol.
JournalJournal of Clinical Pathology
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