A randomized trial of two types of adjuvant chemotherapy in radiotherapy-treated patients with clinical stages I and II high-grade non-Hodgkin's lymphoma.
Authors
Wagstaff, JohnTodd, Ian D
Deakin, David P
Wilkinson, Peter M
Scarffe, J Howard
Harris, Martin
Jones, M
Crowther, Derek
Issue Date
1987
Metadata
Show full item recordAbstract
This paper reports the 8-year results of comparing the use of two types of adjuvant chemotherapy following involved field radiotherapy for clinical stages I and II high-grade non-Hodgkin's lymphoma. Twenty-four patients received 6 weeks of VAP plus 2 years of oral maintenance chemotherapy, and 30 had six cycles of CMOPP. Four patients were not in complete remission at completion of i.v. chemotherapy (CR rate 91%). Ten patients (18.5%) have relapsed (VAP/M = 5; CMOPP = 5), with only two of these remaining alive, both of them being disease free. There have been three deaths from intercurrent causes, one from malignant melanoma and the other two from myocardial infarction. The relapse-free survivals at 2, 5 and 8 years were 80%, 76% & 76% respectively. The overall survivals at the same time points were 86%, 72% & 68%. There were no significant differences in either relapse-free or overall survival for either of the two treatment groups. The shorter period of weekly intravenous chemotherapy (VAP/M) was better tolerated than 36 weeks of CMOPP, and the former appears to produce equivalent results.Citation
A randomized trial of two types of adjuvant chemotherapy in radiotherapy-treated patients with clinical stages I and II high-grade non-Hodgkin's lymphoma. 1987, 20 (1):53-8 Cancer Chemother. Pharmacol.Journal
Cancer Chemotherapy and PharmacologyDOI
10.1007/BF00252960PubMed ID
3304688Type
ArticleLanguage
enISSN
0344-5704ae974a485f413a2113503eed53cd6c53
10.1007/BF00252960
Scopus Count
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