• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    DNA analysis by flow cytometry, response to endocrine treatment and prognosis in advanced carcinoma of the breast.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Baildam, Andrew D
    Zaloudik, J
    Howell, Anthony
    Barnes, Diana M
    Turnbull, Lesley
    Swindell, Ric
    Moore, Michael
    Sellwood, R A
    Issue Date
    1987-05
    
    Metadata
    Show full item record
    Abstract
    The relationship between DNA content of mammary cancer and subsequent response to endocrine therapy was studied in 136 patients with advanced disease. All were treated with tamoxifen or ovarian ablation as first-line systemic therapy after relapse and were evaluable for response according to UICC criteria. DNA characterisation by flow cytometry was used on formalin fixed paraffin-embedded samples of tumour. Tumours were grouped according to DNA index into diploid (n = 52, 38%), 'tetraploid' (n = 46, 34%) and 'other DNA-aneuploid' (n = 38, 28%). The highest proportion of oestrogen receptor positive tumours (ER + ve) was found in the 'tetraploid' tumours (38/46, 85%, Chi-square = 8.53, P less than 0.02), and response rates, (SD + PR + CR), were 26/52 (50%), 34/46 (74%), and 15/38 (39%) respectively (Chi-square = 10.88, P less than 0.005). Patients with diploid or 'tetraploid' tumours survived longer and stayed in remission longer than those with 'other DNA-aneuploid' tumours. We suggest that 'tetraploid' or 'near tetraploid' human mammary tumours may comprise a distinct group of endocrine responsive tumours within the overall group of aneuploid tumours. The conventional interpretation of DNA histograms, grouping into diploid and aneuploid, may be masking important features of some tumour groups.
    Citation
    DNA analysis by flow cytometry, response to endocrine treatment and prognosis in advanced carcinoma of the breast. 1987, 55 (5):553-9 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/113547
    PubMed ID
    3038158
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Effect of tamoxifen upon cell DNA analysis by flow cytometry in primary carcinoma of the breast.
    • Authors: Baildam AD, Zaloudik J, Howell A, Barnes DM, Moore M, Sellwood RA
    • Issue date: 1987 May
    • Steroid receptor heterogeneity in relation to DNA index in breast cancer: a multiparameter flow cytometric approach on paraffin-embedded tumor samples.
    • Authors: Leers MP, Nap M
    • Issue date: 2001 Jul-Aug
    • The influence of age on the DNA ploidy levels of breast tumours.
    • Authors: Taylor IW, Musgrove EA, Friedlander ML, Foo MS, Hedley DW
    • Issue date: 1983 May
    • Pure and mixed mucinous breast carcinomas: DNA stemline and prognosis.
    • Authors: Toikkanen S, Eerola E, Ekfors TO
    • Issue date: 1988 Mar
    • Nuclear DNA content in breast carcinomas with neuroendocrine differentiation.
    • Authors: Nesland JM, Pettersen EO, Fosså SD, Høie J, Johannessen JV
    • Issue date: 1986 Nov
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.