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dc.contributor.authorFreedman, L
dc.contributor.authorParkinson, M
dc.contributor.authorJones, W
dc.contributor.authorOliver, R
dc.contributor.authorPeckham, M
dc.contributor.authorRead, G
dc.contributor.authorNewlands, E
dc.contributor.authorWilliams, C
dc.date.accessioned2010-10-20T08:43:19Z
dc.date.available2010-10-20T08:43:19Z
dc.date.issued1987-08-08
dc.identifier.citationHistopathology in the prediction of relapse of patients with stage I testicular teratoma treated by orchidectomy alone. 1987, 2 (8554):294-8 Lanceten
dc.identifier.issn0140-6736
dc.identifier.pmid2886764
dc.identifier.doi10.1016/S0140-6736(87)90889-0
dc.identifier.urihttp://hdl.handle.net/10541/113526
dc.description.abstract259 patients with stage I non-seminomatous germ-cell testicular teratoma who were treated by orchidectomy alone and monitored at one often centres in the United Kingdom were followed for a median of 30 months. 62 of the 70 relapses occurred in the first 18 months after orchidectomy. The 2-year relapse-free rate was 74%, falling to 68% at 4 years. Histological sections from 233 of the orchidectomy specimens were reviewed centrally. Four features independently predicted relapses: invasion of testicular veins, invasion of testicular lymphatics, absence of yolk-sac elements, and presence of undifferentiated tumour. An index, based on the number of these features observed, identified a high-risk subgroup of 55 patients who had a 42% relapse-free rate at 2 years.
dc.language.isoenen
dc.subjectCancer Stagingen
dc.subjectTesticular Canceren
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshLymphatic Metastasis
dc.subject.meshMale
dc.subject.meshNeoplasm Staging
dc.subject.meshOrchiectomy
dc.subject.meshPrognosis
dc.subject.meshRegression Analysis
dc.subject.meshRetrospective Studies
dc.subject.meshTeratoma
dc.subject.meshTesticular Neoplasms
dc.subject.meshTestis
dc.titleHistopathology in the prediction of relapse of patients with stage I testicular teratoma treated by orchidectomy alone.en
dc.typeArticleen
dc.identifier.journalLanceten
html.description.abstract259 patients with stage I non-seminomatous germ-cell testicular teratoma who were treated by orchidectomy alone and monitored at one often centres in the United Kingdom were followed for a median of 30 months. 62 of the 70 relapses occurred in the first 18 months after orchidectomy. The 2-year relapse-free rate was 74%, falling to 68% at 4 years. Histological sections from 233 of the orchidectomy specimens were reviewed centrally. Four features independently predicted relapses: invasion of testicular veins, invasion of testicular lymphatics, absence of yolk-sac elements, and presence of undifferentiated tumour. An index, based on the number of these features observed, identified a high-risk subgroup of 55 patients who had a 42% relapse-free rate at 2 years.


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