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    An ESR spin label study of childhood kidney tumours.

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    Authors
    Dodd, Nicholas J F
    Kumar, Shant
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1987
    
    Metadata
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    Abstract
    The isolated membranes of cells from normal kidneys, foetal kidneys, Wilms' tumours, and bone-metastasizing renal tumours of childhood (BMRTC) have been examined by electron spin resonance, using the lipophilic spin label 5-doxyl stearic acid. No differences in membrane rigidity were detected between normal kidney cells and Wilms' tumour cells, over the temperature range 5 to 40 degrees C. The membranes of foetal kidney cells showed no significant difference at physiological temperatures, but were more rigid than the membranes of normal kidney cells at lower temperatures. In contrast, BMRTC cells showed lower membrane rigidity than normal kidney cells at all temperatures studied, BMRTC cells, unlike normal kidney and Wilms' tumour cells, lack surface fibronectin, but addition of fibronectin to BMRTC cell membranes, in suspension, had no detectable effect on their rigidity.
    Citation
    An ESR spin label study of childhood kidney tumours., 7 (4B):761-4 Anticancer Res.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/113522
    PubMed ID
    2823683
    Type
    Article
    Language
    en
    ISSN
    0250-7005
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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