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    A phase I study of recombinant interferon gamma administered by s.c. injection three times per week in patients with solid tumours.

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    Authors
    Wagstaff, John
    Smith, David B
    Nelmes, P
    Loynds, P
    Crowther, Derek
    Issue Date
    1987
    
    Metadata
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    Abstract
    Human recombinant DNA interferon gamma (IFN-G), with a specific activity of 2 X 10(6) IU/mg protein, was administered s.c. 3 days per week for 2 months to patients with solid tumors. The maximum tolerated dose (MTD) was 10 X 10(6) IU/m2 (5.0 mg/m2) per injection, and six patients were treated at the MTD. Two of these ceased treatment because of severe subjective toxicity (headache, rigors and pyrexia) and three patients developed WHO grade 3 leucopenia. Subjective toxicity varied considerably between patients and some patients at low dose levels experienced severe constitutional symptoms whilst others treated at the MTD had few side effects. These differences were unrelated to pharmacokinetic parameters. Bioavailability of this IFN-G administered s.c. was very variable from one patient to another at the same dose level. We therefore counsel caution in using this IFN-G preparation s.c. in phase II studies.
    Citation
    A phase I study of recombinant interferon gamma administered by s.c. injection three times per week in patients with solid tumours. 1987, 25 (1):54-8 Cancer Immunol. Immunother.
    Journal
    Cancer Immunology, Immunotherapy
    URI
    http://hdl.handle.net/10541/113518
    DOI
    10.1007/BF00199301
    PubMed ID
    3109738
    Type
    Article
    Language
    en
    ISSN
    0340-7004
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00199301
    Scopus Count
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    All Christie Publications

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