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    A phase II study of oral weekly 4-demethoxydaunorubicin in advanced breast cancer.

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    Authors
    Smith, David B
    Howell, Anthony
    Issue Date
    1987-04
    
    Metadata
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    Abstract
    Thirty-eight patients with advanced breast cancer were treated with oral 4-demethoxydaunorubicin in a continuous weekly schedule at a dose of 15 mg/m2/week. Subjective toxicity consisted of mild nausea (grade 1) in 52% with more severe GI side effects (grade 2) in 15%. Three patients developed grade 1 alopecia and there were no episodes of cardiac failure. Significant neutropenia (grade 2/3) only occurred in patients with marrow involvement or widespread bone disease. There was one CR and 5 PRs, an overall response rate of 15.7% (95% confidence limits 6-31%). In addition 6 patients had disease stabilization for at least 6 months. Fourteen patients progressing on 4-demethoxydaunorubicin have received adriamycin 60 mg/m2 21 days. There have been 5 PRs in this group indicating possible non-cross-resistance between these two agents.
    Citation
    A phase II study of oral weekly 4-demethoxydaunorubicin in advanced breast cancer. 1987, 23 (4):391-4 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/113517
    DOI
    10.1016/0277-5379(87)90375-0
    PubMed ID
    3475204
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(87)90375-0
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