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dc.contributor.authorHaggie, J Aen
dc.contributor.authorSellwood, R Aen
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorSchor, Seth Len
dc.date.accessioned2010-10-20T08:52:23Z
dc.date.available2010-10-20T08:52:23Z
dc.date.issued1987-06-27
dc.identifier.citationFibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro. 1987, 1 (8548):1455-7 Lanceten
dc.identifier.issn0140-6736
dc.identifier.pmid2885452
dc.identifier.doi10.1016/S0140-6736(87)92206-9
dc.identifier.urihttp://hdl.handle.net/10541/113509
dc.description.abstractFetal and normal adult skin fibroblasts show distinctive migratory behaviour when plated on three-dimensional collagen gels. Skin fibroblasts from 13 of 15 patients with hereditary breast cancer showed fetal-like behaviour compared with only 1 of 12 age-matched healthy controls (p less than 0.015; Wilcoxon signed-rank matched-pairs test). In addition, 10 of 15 first-degree relatives of patients with hereditary breast cancer showed a fetal-like fibroblast phenotype, compared with none of 7 surgical controls (p less than 0.009; chi 2 test). These results suggest that abnormalities expressed by skin fibroblasts may help identify people at increased risk of breast cancer developing.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectFoetusen
dc.subject.meshAdult
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Movement
dc.subject.meshEpithelial Cells
dc.subject.meshFemale
dc.subject.meshFetus
dc.subject.meshFibroblasts
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPhenotype
dc.subject.meshSkin
dc.titleFibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro.en
dc.typeArticleen
dc.identifier.journalLanceten
html.description.abstractFetal and normal adult skin fibroblasts show distinctive migratory behaviour when plated on three-dimensional collagen gels. Skin fibroblasts from 13 of 15 patients with hereditary breast cancer showed fetal-like behaviour compared with only 1 of 12 age-matched healthy controls (p less than 0.015; Wilcoxon signed-rank matched-pairs test). In addition, 10 of 15 first-degree relatives of patients with hereditary breast cancer showed a fetal-like fibroblast phenotype, compared with none of 7 surgical controls (p less than 0.009; chi 2 test). These results suggest that abnormalities expressed by skin fibroblasts may help identify people at increased risk of breast cancer developing.


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