Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro.
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AbstractFetal and normal adult skin fibroblasts show distinctive migratory behaviour when plated on three-dimensional collagen gels. Skin fibroblasts from 13 of 15 patients with hereditary breast cancer showed fetal-like behaviour compared with only 1 of 12 age-matched healthy controls (p less than 0.015; Wilcoxon signed-rank matched-pairs test). In addition, 10 of 15 first-degree relatives of patients with hereditary breast cancer showed a fetal-like fibroblast phenotype, compared with none of 7 surgical controls (p less than 0.009; chi 2 test). These results suggest that abnormalities expressed by skin fibroblasts may help identify people at increased risk of breast cancer developing.
CitationFibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro. 1987, 1 (8548):1455-7 Lancet