The pituitary gland and age-dependent regulation of body composition.
Name:
The pituitary gland and age-de ...
Size:
228.6Kb
Format:
PDF
Description:
Main article
Authors
Van Beek, André PWolffenbuttel, Bruce H R
Runge, Evelien
Trainer, Peter J
Jönsson, Peter J
Koltowska-Häggström, Maria
Affiliation
Department of Endocrinology, University Medical Center Groningen, University of Groningen, De Brug 4.069, AA 31, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. a.p.van.beek@int.umcg.nlIssue Date
2010-08
Metadata
Show full item recordAbstract
CONTEXT: The prevalence of obesity is increased in hypopituitarism. In the general population, body mass index (BMI) and waist circumference increase with advancing age. It remains uncertain whether age-related changes in pituitary function contribute to the changes in body composition associated with advancing years. OBJECTIVE: Our objective was to study the relationship between pituitary function, body composition, and age in a large cohort of patients with hypopituitarism and a matched reference population. DESIGN, SETTING, AND PARTICIPANTS: A total of 3632 GH-deficient adults with hypopituitarism, adequately replaced with all pituitary hormones except for GH, from the prospective KIMS database (Pfizer International Metabolic Database) were included in present analysis. A random sample of the general population (3427 subjects) was used as reference. Patients and controls were grouped by gender in five age cohorts of 10 yr from 28 yr onward. MAIN OUTCOME MEASURES: Differences in BMI and waist circumference were evaluated. RESULTS: Patients had a significantly higher BMI and waist circumference than controls, with larger differences at younger age. With advancing age, an increase in BMI and waist circumference was seen in controls but was virtually absent in the patients with adult-onset GH deficiency and hypopituitarism. CONCLUSION: Patients with hypopituitarism have more excess body fat than age-matched controls, especially in the youngest age groups. The normal increase in fat mass with advancing age is not seen in adult-onset GH-deficient hypopituitarism, suggesting a potential role for the normal pituitary gland as an age-dependent regulator of body composition in adult life.Citation
The pituitary gland and age-dependent regulation of body composition. 2010, 95 (8):3664-74 J. Clin Endocrinol MetabJournal
The Journal of Clinical Endocrinology and MetabolismDOI
10.1210/jc.2009-2506PubMed ID
20484487Type
ArticleLanguage
enISSN
1945-7197ae974a485f413a2113503eed53cd6c53
10.1210/jc.2009-2506
Scopus Count
Related articles
- Improvements in Body Composition after 4 Years of Growth Hormone Treatment in Adult-Onset Hypopituitarism Compared to Age-Matched Controls.
- Authors: Postma MR, van Beek AP, Jönsson PJ, van Bunderen CC, Drent ML, Mattsson AF, Camacho-Hubner C
- Issue date: 2019
- Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis.
- Authors: Abs R, Feldt-Rasmussen U, Mattsson AF, Monson JP, Bengtsson BA, Góth MI, Wilton P, Koltowska-Häggström M
- Issue date: 2006 Jul
- Aspects of growth hormone deficiency and replacement in elderly hypopituitary adults.
- Authors: Feldt-Rasmussen U, Wilton P, Jonsson P, KIMS Study Group, KIMS International Board
- Issue date: 2004 Jun
- Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database.
- Authors: Abs R, Mattsson AF, Bengtsson BA, Feldt-Rasmussen U, Góth MI, Koltowska-Häggström M, Monson JP, Verhelst J, Wilton P, KIMS Study Group
- Issue date: 2005 Oct
- Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database).
- Authors: Verhelst J, Kendall-Taylor P, Erfurth EM, Price DA, Geffner M, Koltowska-Häggström M, Jönsson PJ, Wilton P, Abs R
- Issue date: 2005 Aug