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    Detection of ras gene alterations and ras proteins in colorectal cancer.

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    Authors
    Salhab, Nabil
    Jones, David J
    Bos, J L
    Kinsella, Anne R
    Schofield, Philip F
    Affiliation
    Department of Surgery, Christie Hospital and Holt Radium Institute, Manchester, England.
    Issue Date
    1989-08
    
    Metadata
    Show full item record
    Abstract
    DNA extracted from 31 primary colorectal carcinomas was analyzed for the presence of ras gene amplification and mutations. Nine carcinomas had Ha-ras amplification and seven Ki-ras amplification. Nine carcinomas had codon 12 Ki-ras mutations. Immunohistochemical staining for ras proteins revealed a normal membrane association in normal mucosa and benign polyps but an abnormal cytoplasmic distribution in carcinomas. Amplification, mutations, and immunohistochemical staining were independent of histologic differentiation, Dukes' stage, or DNA ploidy status. This study demonstrates that abnormalities of ras genes are a common finding in colorectal carcinomas. They are potentially important biologic changes associated with malignancy, although they do not appear to be related to clinical behavior.
    Citation
    Detection of ras gene alterations and ras proteins in colorectal cancer. 1989, 32 (8):659-64 Dis. Colon Rectum
    Journal
    Diseases of the Colon and Rectum
    URI
    http://hdl.handle.net/10541/111388
    DOI
    10.1007/BF02555769
    PubMed ID
    2666051
    Type
    Article
    Language
    en
    ISSN
    0012-3706
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF02555769
    Scopus Count
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    All Paterson Institute for Cancer Research

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